Biology 2014-2015

DNA Replication
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Section 12-2

  • Replication is the process of DNA duplication

1. DNA helicase separates DNA strands ("unzips")

 

2. Complimentary nucleotide bases hydrogen bond to

DNA bases

3. DNA polymerise (enzyme) catalyzes sugar­ phosphate bond

 

 formation.

 

4. Two new identical DNA molecules result

  • Since adenine (A) can only pair with thymine (T) and cytosine (C)can only pair with guanine (G) the sequence of the new molecule exactly matches the old molecule
  • The copying does not begin at one end and end at another, but rather at many points along the molecule.
  • (If we started from top to bottom with one strand of DNA for a fruit   fly it would take 16 days as opposed to 3 minutes because 6,000 sites are being copied at the same time) 
  • The cell has a built in "proof reading" system (enzymes or proteins) to ensure accuracy (one error per billion)
  • DNA can be broken down by body heat, radiation, chemicals or other factors so 20 or more repair enzymes recognize and remove damaged nucleotides and replace them with new ones.